Introduction: «To each flower its own special attendant.»

Each rhodopsin molecule binds its own arrestin.

Arrestins (Arrs) are ubiquitous regulators of the most numerous family of signaling proteins, G protein-coupled receptors. Two models of the Arr-receptor interaction have been proposed: the binding of one Arr to an individual receptor or to two receptors in a dimer. To determine the binding stoichiometry in vivo, we used rod photoreceptors where rhodopsin (Rh) and Arr are expressed at comparabl...

Motif) to Each (mhc Molecule) Its Own (binding

To Each His Own: DEHP Yields Species-Specific Metabolic Phenotypes

Asthma is now the most common chronic disease for children and a major cause of emergency room visits, hospitalizations, and school absences, according to the World Health Organization. Now a large population-based study has shown an association between elevated exposure to air pollution in utero and during the first year of life and a higher risk of asthma in preschool-aged children [EHP 118:2...

In condoms we trust: to each, one's own.

Introduction to Special Issue

Although recent frameworks for test validation have emphasized utilization as a key component (e.g. Bachman & Palmer, 2010; Chapelle, 2012; Kane, 1992), what happens in the sometimes messy contexts where assessments are carried out is often not documented. This is perhaps because test developers are more focused on defining and operationalizing test constructs than on issues of implementation. ...